My research subject has been on Reta for about 3 months now. We kicked things off at 0.25mg and worked up to 1mg, and we've been holding at 1mg for the last 4 weeks.
The problem is that ever since hitting the 1mg dose, the subject has had diarrhea, even though that's still a pretty low amount. And the frustrating part is there's basically no benefit to go with it — no appetite suppression at all, and no real fat loss since starting. The only thing that's dropped is water weight, maybe 2kg total.
The Reta itself has been tested, including third-party testing, and it works completely fine for another subject I'm running. So I don't think it's a quality issue. But the diarrhea is making it hard to push up to higher doses.
Is there anything that actually helps with the diarrhea aside from watching the diet? The subject already eats low fat, gets plenty of fiber, keeps sugar low, avoids artificial sweeteners, and tracks everything that goes in.