Curious if anyone here has experimented with combining reta and tirz. Would love to hear how it's working out for you — what doses you're running, how you structured it, and what kind of results or side effects you've noticed. Appreciate any input!

Yeah the diarrhea at 1mg is super common, even when everything else looks fine. Splitting into 0.5mg twice a week instead of one full dose can really help the GI system handle it better, and timing the injection either first thing in the morning or right before bed seems to make a noticeable difference for a lot of subjects too.

On the lack of effects, some just take a really long time to respond - had one that didn't show real appetite suppression until week 8 or 9 despite getting sides almost immediately, so that 2kg water drop early on is pretty typical before the real changes kick in. Throwing some probiotics in the mix might help stabilize things in the meantime while the subject adjusts.